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Adunarea Generala Ordinara a Actionarilor 23 Aprilie 2019

Agenda Situatia Rezultatului Global Bugetul de Venituri si Cheltuieli 2019 Plan de Investitii Evolutie numerar si echivalente numerar Pozitia companiei pe piata Intrebari si Raspunsuri

Evolutia indicatorilor financiari vs. +9% 285,5 262,4 +8% 170,2 184,2 49,5 +18% 58,5 36,0 +7% 38,4 Cifra Afaceri Active Totale EBITDA Profit Net

Buget venituri si cheltuieli 2019 Realizat Realizat Buget 2019 Realizat / Bugetat 2019 /Realizat Venituri din vanzari 170,232,296 184,236,168 202,839,302 8% 10% Alte venituri din exploatare 487,491 1,218,322 650,000 150% -47% Variatia stocurilor (50,747) 216,379 1,200,000-526% 455% Materii prime si consumabile (39,527,901) (40,475,299) (45,368,147) 2% 12% Cheltuieli de personal (26,173,666) (31,087,336) (34,706,081) 19% 12% Amortizare (7,058,665) (12,094,830) (10,698,756) 71% -12% Alte cheltuieli din exploatare (55,421,929) (55,594,115) (65,472,021) 0% 18% Profit/ (Pierdere) din exploatare 42,486,879 46,419,289 48,444,298 9% 4% Venituri/(costuri) financiare nete 191,143 754,446 840,000 295% 11% Profit/ (Pierdere) inainte de impozitare 42,678,022 47,173,735 49,284,298 11% 4% Cheltuieli cu impozite (6,650,299) (8,748,795) (7,885,488) 32% -10% Profit/(Pierdere) 36,027,723 38,424,940 41,398,810 7% 8% Nota: 1. Pentru anul 2019 in categoria cheltuieli de personal a fost prevazuta suma de 1.200.000 lei pentru tichete de masa si suma de 300.000 lei tichete cadou oferite angajatilor ca ajutoare sociale, conform legislatiei in vigoare 2. Pentru sustinerea activitatii de promovare in piata a produselor Biofarm, in cadrul bugetului 2019 a fost prevazuta in categoria Alte cheltuieli din exploatare o suma de pana la 1.000.000 lei pentru tichete cadou. 3. In conditiile in care evolutia pietei permite depasirea cifrei de afaceri si/sau atingerea tintei de profit net, se pot angaja cheltuieli suplimentare.

Plan de Investitii 2019 Descriere CAPEX Ron aprobat Contractat CAPEX Ron aprobat - neangajat CAPEX aditional 2019 CAPEX 2019 Lucrari 2,380,800 272,182 2,108,618 2,662,757 4,771,375 Instalatii 4,445,400 910,095 3,535,305 3,391,952 6,927,258 Echipamente 26,346,900 9,090,451 17,256,449 4,826,301 22,082,750 Echipamente de productie Fabrica Logofatul Tautu 651,930 530,800 121,130 (121,130) Echipamente de laborator 560,325 117,319 443,006 (443,006) Amenajare cladiri si spatii comune 593,750 593,750 Investitii auto 2,790,000 846,215 1,943,785 (708,785) 1,235,000 IT echipamente si software 2,148,347 333,887 1,814,460 (433,350) 1,381,110 TOTAL 39,323,702 12,100,948 27,222,754 9,768,489 36,991,243 Nota: Activele mentionate in Planul de Investitii pentru fabrica noua din Gura Badicului vor fi achizitionate progresiv, in functie de finalizarea cladirilor si a spatiilor de productie.

Evolutie numerar si echivalente numerar 60 55 50 45 40 35 30 25 20 15 10 5 0 17-Dec Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov 45,7 37,0 17,6 15,4 12,8 Dec +26% +15% Incasari Cifra afaceri Plati Valoare depozite Disponibil final

Pozitia companiei pe piata Rank CORPORATION Units Units UC Evolutie vs MS TOTAL PIATA FARMACEUTICA 578,623,808 612,663,191 5.88% 1 SUN PHARMA 50,100,435 54,902,912 9.59% 8.96% 2 ZENTIVA 37,043,503 38,973,842 5.21% 6.36% 3 SERVIER 33,539,063 36,618,507 9.18% 5.98% 4 KRKA D.D. 32,201,598 33,981,628 5.53% 5.55% 5 ANTIBIOTICE 31,340,136 32,086,728 2.38% 5.24% 6 SANOFI 26,817,888 29,942,313 11.65% 4.89% 7 GLAXOSMITHKLINE 25,344,777 28,977,909 14.33% 4.73% 8 ALVOGEN 26,962,129 24,960,519-7.42% 4.07% 9 NOVARTIS 23,245,782 22,933,970-1.34% 3.74% 10 GEDEON RICHTER 20,860,159 21,819,521 4.60% 3.56% 11 BIOFARM 19,798,841 21,348,282 7.83% 3.48% Rank CORPORATION Values PPP Values PPP VAL PPP Evolutie vs MS TOTAL PIATA FARMACEUTICA 14,121,579,465 16,068,719,842 13.79% 1 ABBVIE 1,100,061,882 1,086,078,394-1.27% 6.76% 2 SANOFI 666,755,500 809,285,935 21.38% 5.04% 3 MERCK & CO 348,662,398 722,302,608 107.16% 4.50% 4 NOVARTIS 626,239,740 708,324,866 13.11% 4.41% 5 SERVIER 626,654,888 689,075,005 9.96% 4.29% 6 GLAXOSMITHKLINE 570,855,034 663,526,434 16.23% 4.13% 7 SUN PHARMA 553,444,921 632,262,641 14.24% 3.93% 8 PFIZER 578,907,976 625,795,555 8.10% 3.89% 9 ASTRAZENECA 466,788,381 547,023,141 17.19% 3.40% 10 BRISTOL MYERS SQUIBB 415,383,996 496,181,188 19.45% 3.09% 23 BIOFARM 199,993,214 227,697,283 13.85% 1.42% Rank CORPORATION Units Units UC Evolutie vs MS TOTAL PIATA OTC + SN 194,090,484 207,924,911 7.13% 1 SUN PHARMA 20,395,494 21,650,317 6.15% 10.41% 2 BIOFARM 16,696,491 18,368,099 10.01% 8.83% 3 SANOFI 13,315,408 15,770,198 18.44% 7.58% 4 GLAXOSMITHKLINE 12,819,417 14,596,440 13.86% 7.02% 5 RECKITT BENCKISER 12,404,456 14,506,847 16.95% 6.98% 6 ALVOGEN 7,317,869 6,663,741-8.94% 3.20% 7 BAYER HEALTHCARE AG 6,549,864 6,551,967 0.03% 3.15% 8 NATUR PRODUKT ZDROVIT 4,838,110 6,219,246 28.55% 2.99% 9 NOVARTIS 5,154,248 5,624,159 9.12% 2.70% 10 FITERMAN PHARMA 5,943,795 5,373,508-9.59% 2.58% Rank CORPORATION Values PPP Values PPP VAL PPP Evolutie vs MS TOTAL PIATA OTC + SN 3,104,491,542 3,552,229,832 14.42% 1 RECKITT BENCKISER 223,774,010 276,291,672 23.47% 7.78% 2 SUN PHARMA 217,837,027 239,551,974 9.97% 6.74% 3 SANOFI 181,149,516 230,885,015 27.46% 6.50% 4 BIOFARM 187,237,331 215,272,647 14.97% 6.06% 5 GLAXOSMITHKLINE 166,798,120 207,316,242 24.29% 5.84% 6 ASCENDIS HEALTH 154,621,328 183,783,574 18.86% 5.17% 7 NOVARTIS 106,979,179 123,792,278 15.72% 3.48% 8 BAYER HEALTHCARE AG 120,773,374 122,916,568 1.77% 3.46% 9 NATUR PRODUKT ZDROVIT 80,622,092 108,783,079 34.93% 3.06% 10 FITERMAN PHARMA 112,044,641 105,765,417-5.60% 2.98% Sursa Date Cegedim

Pozitia companiei pe piata Rank CORPORATION Units Units UC Evolutie vs MS TOTAL PIATA SN 54,755,871 58,380,854 6.62% 1 BIOFARM 5,525,986 6,045,122 9.39% 10.35% 2 NATUR PRODUKT ZDROVIT 4,596,175 5,843,802 27.14% 10.01% 3 ASCENDIS HEALTH 4,567,451 5,147,977 12.71% 8.82% 4 FITERMAN PHARMA 3,436,488 3,143,539-8.52% 5.38% 5 ALVOGEN 2,496,938 2,476,319-0.83% 4.24% 6 WALMARK 2,567,796 2,443,826-4.83% 4.19% 7 SUN PHARMA 2,428,385 2,398,931-1.21% 4.11% 8 PERRIGO 2,249,646 2,142,827-4.75% 3.67% 9 HIMALAYA 1,711,319 1,806,009 5.53% 3.09% 10 BAYER HEALTHCARE AG 1,566,716 1,780,728 13.66% 3.05% Rank CORPORATION Values PPP Values PPP VAL PPP Evolutie vs MS TOTAL PIATA SN 1,176,948,813 1,347,383,179 14.48% 1 ASCENDIS HEALTH 144,873,083 174,919,141 20.74% 12.98% 2 NATUR PRODUKT ZDROVIT 76,220,117 101,366,410 32.99% 7.52% 3 BIOFARM 70,318,633 82,969,696 17.99% 6.16% 4 WALMARK 77,955,530 80,788,241 3.63% 6.00% 5 FITERMAN PHARMA 60,374,715 58,577,005-2.98% 4.35% 6 ALVOGEN 45,236,520 45,206,130-0.07% 3.36% 7 BAYER HEALTHCARE AG 40,238,110 44,875,233 11.52% 3.33% 8 HIMALAYA 35,546,340 43,276,282 21.75% 3.21% 9 SUN PHARMA 37,816,357 40,185,817 6.27% 2.98% 10 PERRIGO 36,691,714 36,231,613-1.25% 2.69% Rank CORPORATION Units Units UC Evolutie vs MS TOTAL PIATA OTC 139,334,613 149,544,057 7.33% 1 SUN PHARMA 17,967,109 19,251,386 7.15% 12.87% 2 SANOFI 13,213,070 15,625,181 18.26% 10.45% 3 RECKITT BENCKISER 12,404,456 14,506,847 16.95% 9.70% 4 GLAXOSMITHKLINE 12,623,368 14,398,616 14.06% 9.63% 5 BIOFARM 11,170,505 12,322,977 10.32% 8.24% 6 BAYER HEALTHCARE AG 4,983,148 4,771,239-4.25% 3.19% 7 ANTIBIOTICE 4,761,677 4,590,557-3.59% 3.07% 8 GEDEON RICHTER 4,176,270 4,319,494 3.43% 2.89% 9 JOHNSON & JOHNSON 3,801,261 4,224,122 11.12% 2.82% 10 ALVOGEN 4,820,931 4,187,422-13.14% 2.80% Rank CORPORATION Values PPP Values PPP VAL PPP Evolutie vs MS TOTAL PIATA OTC 1,927,542,729 2,204,846,653 14.39% 1 RECKITT BENCKISER 223,774,010 276,291,672 23.47% 12.53% 2 SANOFI 178,949,036 227,118,891 26.92% 10.30% 3 GLAXOSMITHKLINE 160,995,807 200,949,040 24.82% 9.11% 4 SUN PHARMA 180,020,670 199,366,157 10.75% 9.04% 5 BIOFARM 116,918,698 132,302,951 13.16% 6.00% 6 NOVARTIS 78,986,763 87,876,603 11.25% 3.99% 7 BAYER HEALTHCARE AG 80,535,264 78,041,335-3.10% 3.54% 8 MENARINI 63,517,714 66,979,704 5.45% 3.04% 9 JOHNSON & JOHNSON 58,112,550 65,355,198 12.46% 2.96% 10 ANGELINI 45,805,979 57,745,458 26.07% 2.62% Sursa Date Cegedim

Impartirea venitului pe categorii

Pozitia brandurilor in piata 31 de branduri sunt in primele 5 pozitii in categoriile lor 8 Branduri Biofarm sunt nr 1 in categoriile lor ATC4 7 Branduri Biofarm ocupa locul nr 2 16 Branduri Biofarm sunt in pozitiile 3-5 Brand Biofarm MS Units BIXTONIM SOLUTIE 34.35% CARMOL SOLUTIE 94.24% COLEBIL 55.49% HERBAFLU INHALANT 94.96% NERVOCALMIN 16.61% TRIFERMENT 58.10% Vitamina A 99.34% Vitamina E 92.05% Brand Biofarm MS Units BIXTONIM XYLO 27.75% BROCRIPTIN 16.24% CARBOCIT 29.58% COLCHICINA 12.64% EXTRAVALERIANIC BIOFARM CARDIO 17.61% SENNALAX COMPRIMATE, SIROPURI 36.01% VITAMINA A + D2 30.97% Brand Biofarm MS Units ANGHIROL 10.41% BORAMID 12.90% DEVARICID COMPRIMATE 9.20% HEPATOPROTECT 9.99% SOL CLORAMFENICOL FLUOCINOLONL 28.86% CAVIT 7.58% MAGNEFORT 9.13% METOCLOPRAMID 3.58% OSSIDENTA 10.38% PROTECARDIN 2.14% VERMIGAL 10.46% BIOLAND ULEI DE PESTE D2 3.28% DIABETICARE 2.71% DIFEBIOM 7.25% ROFEDEX SIROP 5.14% VITAMINA D3 3.25% Cu cele 62 de branduri suntem prezenti in 10 piete din CEGEDIM : tract digestiv sistem respirator sistem nervos sistem cardiovascular dermatologie tract urinar sistem musculo-scheletal parazitologie sensory organs Sistem sangvin Sursa Date Cegedim

Evolutie principalele branduri BIOFARM Values PPP Values PPP Values PPP % Growth on Any Ref Values PPP ABS Growth on Any Ref MS BIOFARM Values PPP RANK (Values PPP ) 199,993,222 227,697,284 13.85% 27,704,062 TRIFERMENT 28,047,660 31,579,856 12.59% 3,532,196 52.22% 1 COLEBIL 27,159,443 28,309,517 4.23% 1,150,074 51.61% 1 BIXTONIM XYLO 14,829,304 15,660,136 5.60% 830,832 25.79% 2 HEPATOPROTECT 11,716,921 15,474,779 32.07% 3,757,858 7.59% 5 CARMOL SOLUTIE 9,714,146 14,562,226 49.91% 4,848,080 96.96% 1 BIXTONIM SOLUTIE 11,773,978 13,408,952 13.89% 1,634,974 20.92% 2 SENNALAX COMPRIMATE, SIROPURI 10,255,239 12,403,723 20.95% 2,148,484 32.25% 2 DEVARICID COMPRIMATE 9,558,309 10,081,772 5.48% 523,463 7.56% 3 NERVOCALMIN 5,380,285 6,855,120 27.41% 1,474,835 14.03% 3 CARBOCIT 6,090,316 6,608,270 8.50% 517,954 20.34% 3 ANGHIROL 5,618,379 6,593,326 17.35% 974,947 12.02% 3 EXTRAVALERIANIC BIOFARM CARDIO 3,901,223 5,487,079 40.65% 1,585,856 31.90% 2 PROTECARDIN 2,522,452 2,190,637-13.15% -331,815 1.83% 4 OTHERS 53,425,567 58,481,891 9.46% 5,056,324 Sursa: Date CEGEDIM

Principalele branduri Biofarm vs. competitorii relevanti ATC4 CORPORATION BRAND A9A0 (DIGESTIVES, INCLUDING ENZYMES) MS Values PPP RANK BIOFARM TRIFERMENT 52.22% 1 MYLAN KREON 16.78% 2 ALVOGEN DIGENZYM PLUS 10.24% 3 ATC4 CORPORATION BRAND A6A2 (STIMULANT LAXATIVES) MS Values PPP RANK SANOFI DULCOLAX 35.96% 1 BIOFARM SENNALAX 32.25% 2 SOLACIUM PHARMA SOLACIUM PHARMA 7.31% 3 A5A1 (CHOLERETICS AND CHOLEKINETICS) BIOFARM COLEBIL 51.61% 1 SUN PHARMA FIOBILIN 17.38% 2 BIOFARM ANGHIROL 12.02% 3 PHARCO PHARM. BILICHOL 5.78% 4 ROWA WAGNER ROWACHOL 4.70% 5 C5C0 (VARICOSE THERAPY, SYSTEMIC) SERVIER DETRALEX 70.15% 1 ANTIBIOTICE FLUXIV 8.21% 2 BIOFARM DEVARICID 7.56% 3 A5B0 (HEPATIC PROTECTORS, LIPOTROPICS) R1A7 (NASAL DECONGESTANTS) NASAL CORTICOSTEROIDS WITHOUT ANTI-INFECTIVES) M2A0 (TOPICAL ANTI-RHEUMATICS AND ANALGESICS) SANOFI ESSENTIALE FORTE 22.78% 1 HIMALAYA LIV 52 9.86% 2 SUN PHARMA FORTIFIKAT 8.30% 3 WORWAG PHARMA LAGOSA 7.60% 4 BIOFARM HEPATOPROTECT 7.59% 5 JOHNSON & JOHNSON OLYNTH 44.63% 1 BIOFARM BIXTONIM XYLO 25.79% 2 GLAXOSMITHKLINE VIBROCIL 7.58% 3 LAB. THEA BIORINIL 29.69% 1 BIOFARM BIXTONIM solutie 20.92% 2 MERCK & CO NASONEX 11.82% 3 BIOFARM CARMOL (fara gel) 96.96% 1 TIS FARMACEUTIC SALMET T sol.ext. 1.34% 2 LAROPHARM LAROGRIP 1.62% 3 N5B5 (HERBAL HYPNOTICS/SEDATIVES) A2A2 (PLAIN ANTIFLATULENTS AND CARMINATIVES) fara suspensiile pentru copii CARDIOVASCULAR PRODUCTS B1C1 (CYCLO-OXIGENASE INHIBITOR PLATELET AGGREGATION INHIBITORS) ASCENDIS HEALTH STRESCLIN 20.73% 1 LAB. BOI SEDATIF PC 15.20% 2 BIOFARM NERVOCALMIN 14.03% 3 MENARINI ESPUMISAN 46.58% 1 SUN PHARMA KEBENE 23.88% 2 BIOFARM CARBOCIT 20.34% 3 ZENTIVA EXTRAVERAL 53.65% 1 BIOFARM EXTRAVALERIANIC BI 31.90% 2 DR. REDDY'S LAB. VAGOSTABYL 13.29% 3 SUN PHARMA ASPENTER 73.95% 1 BAYER HEALTHCARE AG ASPIRIN CARDIO 13.62% 2 GALENICA AFLEN 3.79% 3 BIOFARM PROTECARDIN 1.83% 4 Sursa Date Cegedim